Cisplatin and apoptosis

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August undefined, 2024

WebSynergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis Synergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis Authors Min Liu 1 , Shumei Ma 2 , Mingbo Liu 2 , Yufei Hou 2 , Bing Liang 2 , Xu Su 3 , Xiaodong Liu 4 Affiliations WebThe manuscript by Bernardo-Bermejo analyses the metabolic differences between apoptotic bodies released by HK-2 cells, upon induction to apoptosis either by cisplatin or UV light. Although the topic may be potentially of interest, the manuscript is unclear, as well as the main findings. In addition, some methodological issues need to be addressed.

LncRNA UCA1 Enhances Cisplatin Resistance by Regulating …

WebSep 5, 2011 · Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma. Clin Cancer Res 15: 1645–1654. WebJan 29, 2024 · Apoptosis and necroptosis were previously reported to be the major pathological processes of acute kidney injury, however, preclinical works using specific inhibitor of neither apoptosis or... flanders data ownership

Mechanisms of Cisplatin-Induced Acute Kidney Injury: …

WebJan 5, 2016 · In conclusion, NF-κB transcriptional inhibition in cisplatin-induced AKI ameliorates kidney function and ATN without a significant effect on apoptosis and is associated with a decrease pro-inflammatory mediators and CARD11. Keywords: Acute kidney injury; Apoptosis; Cisplatin; NF-κB; Necrosis. Copyright © 2015. Published by … WebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for … WebWe have treated four prostate tumor cell lines, DU-145, PC-3, LNCaP and 22RV1 with various concentrations of cisplatin in order to check for influence on viability and for onset of apoptosis induction. At a cisplatin concentration of 20 microM, 22RV1 and DU-145 cells showed approximately 22% and 18% … flanders diamond manufacturing

Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate ...

VDR activation attenuate cisplatin induced AKI by inhibiting ...

WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... adenocarcinoma promotes proliferation via the accumulation of β-catenin 17 and regulates lung tumorigenesis through cell apoptosis and autophagy pathways. 16 USP14 is critical ... WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 … flanders cycling museumWebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... flanders cycling 2021

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Cisplatin and apoptosis

WebIn summary, a growing body of evidence suggests that cisplatin-induced cell death does not always come from "classic"apoptosis. Depending on both cisplatin dose and cellular … WebOct 16, 2006 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis within …

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WebFeb 13, 2024 · Scutellarin is a active flavone extracted from Erigeron breviscapus Hand-Mazz that has been shown to exhibit anticancer activities on various types of tumors. … WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was …

WebMechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment Cisplatin is … WebNational Center for Biotechnology Information

WebMar 25, 2024 · Furthermore, RRS1 also induces apoptosis resistance in breast cancer cells through the ERK/Bcl-2/BAX signaling pathway. Our study is the first to show that RRS1 sensitizes breast cancer cells to cisplatin by binding to AEG-1, and it provides a theoretical basis to improve the efficacy of cisplatin-based chemotherapy. WebFeb 13, 2024 · Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application.

WebCisplatin is a widely used chemotherapeutic agent. Here we show that cisplatin induces apoptosis in renal collecting duct-derived cells (MDCK-C7 cells, resembling principal …

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … flanders cyclingWebTo further confirm that CYP1B1 is the executor of the UCA1/miR-513a-3p/CYP1B1 molecular axis regulating GC cell apoptosis induced by cisplatin, we simultaneously … can rats eat pastaWebMar 29, 2024 · In addition to TNF-α mediated apoptosis, cisplatin activates the p53 pathway, which can be a result of elevated ROS or induced as a response to elevated ROS from the intrinsic pathway. Treatment with cisplatin results in an increased expression and activation of the p53 protein since it regulates apoptosis of proximal tubular cells via ... flanders cycling teamWebDec 12, 2024 · Cisplatin-induced AKI is characterised by increased apoptosis of renal tubular epithelial cells, and the results of the present study demonstrated that PSTPIP2 … flanders cycling 2022WebCisplatin is a type of chemotherapy. It destroys quickly dividing cells, such as cancer cells. Find out more about how chemotherapy works How do you have cisplatin? You have cisplatin as a drip into your bloodstream (intravenously). Into your bloodstream You might have treatment through a long plastic tube that goes into a large vein in your chest. flanders cyclesWebLTTs minimise cisplatin-induced DNA damage and evade apoptosis by increased expression of anti-apoptotic factors. The observed diversity among the four LTTs highlights the complexity of cisplatin resistance mechanisms even within one tumour entity, explaining heterogeneity in patient responses to chemotherapy. flanders dental associatesWebMar 15, 2024 · Cell viability and proliferation were detected by counting kit 8 (CCK-8) and 5-ethynyl-2'-deoxyuridine (EdU) assays respectively. Apoptosis and cell cycle were analyzed by flow cytometry. The results indicated that URI knockdown increased the sensitivity of cells to cisplatin by inhibiting proliferation and promoting apoptosis. can rats eat oats