WebKRT5 / CK5 / Cytokeratin 5 keratin 5. The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is ... WebInitial immunohistochemical stains were positive for NUT, p63 and retained SMARCA4, while negative for Lu-5 (pan-cytokeratin), TTF-1, p40, S100 protein, OCT-4, HMB-45, SMA, and PAX-8. Tempus ×T assay revealed a BRD3-NUTM1 fusion gene. Post-mortem analysis revealed an ill-defined mass abutting the trachea and superior vena cava, as well as a ...
KRT5 gene: MedlinePlus Genetics
WebRoughly half of ER+ tumors contain a predominantly ER− subpopulation that expresses intermediate filament protein cytokeratin 5 (CK5) . Our group and others have shown that CK5+ cells exhibit all the hallmarks of breast cancer stem cells (CSCs) including enhanced tumor initiation, tumorsphere formation, and drug resistance compared to ... WebFormalin-fixed, paraffin-embeded human tonsil tissue stained for Cytokeratin 5 using ab17130 at 1/50 dilution in immunohistochemical analysis. Antigen retrieval with citrate buffer pH 6.0. Flow Cytometry - Anti-Cytokeratin 5 antibody [XM26] (ab17130) cyto set b braun
Understanding Your Pathology Report: Lung Cancer
WebCytokeratin 5 is a type II cytokeratin found in squamous cell epithelium, myoepithelial cells of the breast and the basal cells of the prostate. Both Cytokeratin 5 and its corresponding partner, Cytokeratin 14, are essential for formation of 8-nm filaments. WebThis case was estrogen receptor negative (B) and strongly positive for cytokeratin 5 (C), consistent with the so-called “basal-like ductal carcinoma in situ” phenotype. Overall, the combined ER-high/CK5-low immunoprofile to identify atypical lesions was 93% sensitive and 100% specific, whereas the nonatypical profile of ER-low/CK5-high was ... WebA majority of breast cancers are estrogen receptor (ER) positive and have a luminal epithelial phenotype. However, these ER + tumors often contain heterogeneous … binge discount code